Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	SM_Over_01	7.10e-03	9.13e-01	3.48e-01	1.67e-03
SM_Over_01	JLC	1.14e-01	1.43e-02	1.23e-03	1.11e-04



Evaluating how well JLC genes are linked to SM_Over_01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	SM_Over_01	0.67	0.35	0.28	0.35	4.30
SM_Over_01	JLC	0.81	1.25	2.58	0.98	3.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	SM_Over_01	0.00	0.48	0.97	1.41	2.56
SM_Over_01	JLC	0.00	-0.02	0.59	0.03	1.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
SM_Over_01	46	46