Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	SM_Over_001	3.60e-03	9.46e-01	2.72e-01	3.12e-02
SM_Over_001	JLC	1.61e-01	9.72e-02	3.82e-03	7.39e-03



Evaluating how well JLC genes are linked to SM_Over_001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	SM_Over_001	0.64	-0.34	-0.26	0.13	3.07
SM_Over_001	JLC	0.78	0.99	1.99	0.99	3.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	SM_Over_001	0.00	0.34	0.48	0.85	2.62
SM_Over_001	JLC	0.00	0.40	0.16	0.79	2.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
SM_Over_001	38	38