Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
CovidGS Exclusive	SM_Over_001	2.11e-02	1.14e-01	1.56e-03	4.05e-03
SM_Over_001 Exclusive	CovidGS	2.03e-04	1.40e-04	1.54e-11	3.23e-10
CovidGS Exclusive	SM_Over_001 Exclusive	1.98e-02	2.03e-01	2.99e-03	1.39e-02
SM_Over_001 Exclusive	CovidGS Exclusive	3.33e-05	7.54e-05	1.78e-10	1.11e-09
CovidGS Exclusive	Overlap	5.40e-01	5.27e-01	5.40e-01	5.53e-01
SM_Over_001 Exclusive	Overlap	5.40e-01	5.40e-01	6.06e-01	5.66e-01
Overlap	Exclusives	6.91e-17	2.81e-13	9.83e-17	4.13e-24



Evaluating how well CovidGS genes are linked to SM_Over_001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
CovidGS Exclusive	SM_Over_001	0.68	1.42	1.74	1.85	3.96
SM_Over_001 Exclusive	CovidGS	0.75	1.16	3.68	1.90	8.38
CovidGS Exclusive	SM_Over_001 Exclusive	0.68	0.82	1.60	1.50	3.97
SM_Over_001 Exclusive	CovidGS Exclusive	0.76	1.31	3.89	1.59	8.84
CovidGS Exclusive	Overlap	0.75	2.46	1.63	1.25	1.32
SM_Over_001 Exclusive	Overlap	0.56	0.44	0.06	0.01	0.41
Overlap	Exclusives	0.80	2.25	7.98	1.94	11.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
CovidGS Exclusive	SM_Over_001	0.01	0.73	3.52	4.40	7.58
SM_Over_001 Exclusive	CovidGS	0.02	1.80	10.68	7.19	8.77
CovidGS Exclusive	SM_Over_001 Exclusive	0.00	-0.03	3.07	3.33	0.44
SM_Over_001 Exclusive	CovidGS Exclusive	0.02	2.26	11.64	4.55	8.34
CovidGS Exclusive	Overlap	0.01	3.55	74.01	27.07	6.14
SM_Over_001 Exclusive	Overlap	0.00	0.93	2.19	-0.03	1.75
Overlap	Exclusives	0.03	6.83	25.97	3.85	21.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
CovidGS Exclusive	76	73	HLA-DRB4;MBL3P;SRY
SM_Over_001 Exclusive	36	36	
Overlap	2	2