Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ViralGS Exclusive	SM_Over_001	2.55e-02	1.61e-01	1.38e-03	1.90e-03
SM_Over_001 Exclusive	ViralGS	3.34e-05	1.51e-04	1.40e-11	1.06e-10
ViralGS Exclusive	SM_Over_001 Exclusive	4.16e-02	2.15e-01	2.51e-03	2.06e-03
SM_Over_001 Exclusive	ViralGS Exclusive	1.93e-04	1.77e-04	1.68e-11	4.28e-10
ViralGS Exclusive	Overlap	5.40e-01	5.40e-01	5.40e-01	5.40e-01
SM_Over_001 Exclusive	Overlap	5.40e-01	5.40e-01	6.33e-01	6.60e-01
Overlap	Exclusives	7.51e-25	1.35e-20	3.68e-19	4.02e-35



Evaluating how well ViralGS genes are linked to SM_Over_001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ViralGS Exclusive	SM_Over_001	0.69	1.40	2.32	2.34	4.35
SM_Over_001 Exclusive	ViralGS	0.74	1.40	4.00	1.60	9.69
ViralGS Exclusive	SM_Over_001 Exclusive	0.69	1.05	2.27	1.81	3.89
SM_Over_001 Exclusive	ViralGS Exclusive	0.75	1.20	4.00	1.50	9.50
ViralGS Exclusive	Overlap	0.70	1.78	1.05	0.84	1.08
SM_Over_001 Exclusive	Overlap	0.56	0.40	-0.06	0.23	0.28
Overlap	Exclusives	0.82	2.56	10.50	1.88	14.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ViralGS Exclusive	SM_Over_001	0.00	0.47	2.73	3.86	4.60
SM_Over_001 Exclusive	ViralGS	0.02	2.48	11.09	4.08	19.71
ViralGS Exclusive	SM_Over_001 Exclusive	0.00	-0.09	2.42	2.71	5.27
SM_Over_001 Exclusive	ViralGS Exclusive	0.02	1.96	10.87	4.45	19.88
ViralGS Exclusive	Overlap	0.01	29.82	39.27	6.44	10.52
SM_Over_001 Exclusive	Overlap	0.00	1.11	2.54	0.04	0.16
Overlap	Exclusives	0.03	6.89	31.15	3.49	23.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ViralGS Exclusive	106	102	MBL3P;SNORA31;SRY;HLA-DRB4
SM_Over_001 Exclusive	36	36	
Overlap	2	2