Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ViralGS Exclusive	Cont_Over_01	2.26e-06	8.99e-01	2.12e-02	7.82e-02
Cont_Over_01 Exclusive	ViralGS	6.61e-03	5.49e-07	1.22e-08	9.05e-21
ViralGS Exclusive	Cont_Over_01 Exclusive	6.26e-07	9.77e-01	2.92e-02	8.16e-02
Cont_Over_01 Exclusive	ViralGS Exclusive	1.78e-03	6.93e-07	1.45e-07	1.46e-20
ViralGS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
Cont_Over_01 Exclusive	Overlap	2.06e-01	5.30e-01	1.25e-01	1.75e-01
Overlap	Exclusives	5.30e-17	1.57e-15	1.13e-42	9.01e-24



Evaluating how well ViralGS genes are linked to Cont_Over_01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ViralGS Exclusive	Cont_Over_01	0.57	0.40	0.25	0.46	2.54
Cont_Over_01 Exclusive	ViralGS	0.75	1.25	4.85	1.74	8.53
ViralGS Exclusive	Cont_Over_01 Exclusive	0.57	0.22	0.48	0.33	2.70
Cont_Over_01 Exclusive	ViralGS Exclusive	0.75	1.27	4.48	1.70	8.70
ViralGS Exclusive	Overlap	1.00	1.29	2.95	1.44	1.78
Cont_Over_01 Exclusive	Overlap	0.91	0.61	0.81	0.86	1.28
Overlap	Exclusives	0.72	1.72	7.74	2.44	12.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ViralGS Exclusive	Cont_Over_01	0.01	0.69	1.40	1.15	3.23
Cont_Over_01 Exclusive	ViralGS	0.01	-0.06	2.50	0.97	9.58
ViralGS Exclusive	Cont_Over_01 Exclusive	0.01	0.15	0.85	0.47	1.23
Cont_Over_01 Exclusive	ViralGS Exclusive	0.01	-0.05	2.76	0.64	7.52
ViralGS Exclusive	Overlap	0.01	5.73	127.36	26.71	8.12
Cont_Over_01 Exclusive	Overlap	0.00	-0.10	-0.40	0.42	0.11
Overlap	Exclusives	0.05	9.69	30.96	5.37	53.96

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ViralGS Exclusive	107	103	MBL3P;HLA-DRB4;SRY;SNORA31
Cont_Over_01 Exclusive	124	124	
Overlap	1	1