Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
CovidGS	Cont_Over_01	4.15e-06	9.04e-01	1.92e-02	4.82e-02
Cont_Over_01	CovidGS	1.81e-02	3.44e-07	8.50e-09	2.37e-19



Evaluating how well CovidGS genes are linked to Cont_Over_01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
CovidGS	Cont_Over_01	0.57	0.16	0.15	0.47	2.87
Cont_Over_01	CovidGS	0.78	1.51	5.24	2.05	7.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
CovidGS	Cont_Over_01	0.01	0.09	0.95	0.86	3.16
Cont_Over_01	CovidGS	0.01	-0.08	3.31	0.96	3.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
CovidGS	78	75	HLA-DRB4;SRY;MBL3P
Cont_Over_01	125	125