Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	Cont_Over_01	6.30e-08	1.70e-01	3.66e-02	3.82e-01
Cont_Over_01	JLC	6.63e-01	9.44e-02	5.67e-03	2.97e-04



Evaluating how well JLC genes are linked to Cont_Over_01 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Cont_Over_01	0.54	-0.88	-1.45	-0.64	1.59
Cont_Over_01	JLC	0.82	0.44	2.66	1.29	4.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Cont_Over_01	0.01	0.31	-0.17	0.03	1.91
Cont_Over_01	JLC	0.00	-0.41	1.32	0.40	3.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
Cont_Over_01	125	125