Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	Cont_Over_001	3.05e-08	1.19e-01	2.78e-01	2.46e-01
Cont_Over_001	JLC	3.34e-01	2.23e-02	2.59e-03	1.57e-04



Evaluating how well JLC genes are linked to Cont_Over_001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Cont_Over_001	0.55	-0.66	-1.39	-0.19	1.87
Cont_Over_001	JLC	0.83	0.70	2.68	1.22	3.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Cont_Over_001	0.01	0.21	-0.23	0.13	1.14
Cont_Over_001	JLC	0.00	-0.17	1.39	0.39	1.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
Cont_Over_001	110	110