Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	Control_0001	1.86e-05	2.10e-01	9.18e-05	4.69e-04
Control_0001 Exclusive	Viral	7.11e-02	3.24e-02	3.72e-06	1.26e-09
Viral Exclusive	Control_0001 Exclusive	2.57e-05	3.45e-01	3.28e-04	3.61e-04
Control_0001 Exclusive	Viral Exclusive	7.88e-02	3.94e-02	2.16e-04	3.30e-09
Viral Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Control_0001 Exclusive	Overlap	2.55e-02	7.69e-02	1.28e-02	1.82e-02
Overlap	Exclusives	9.68e-25	1.78e-18	1.24e-38	7.32e-28



Evaluating how well Viral genes are linked to Control_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Control_0001	0.62	1.10	1.48	0.83	4.72
Control_0001 Exclusive	Viral	0.70	0.08	3.22	1.11	6.98
Viral Exclusive	Control_0001 Exclusive	0.62	1.25	1.21	0.83	4.56
Control_0001 Exclusive	Viral Exclusive	0.70	0.06	2.92	0.87	5.89
Viral Exclusive	Overlap	1.00	1.52	6.47	1.90	2.25
Control_0001 Exclusive	Overlap	0.93	0.63	2.50	1.09	2.18
Overlap	Exclusives	0.75	3.48	8.09	2.12	13.78

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Control_0001	0.01	0.80	0.66	1.14	2.15
Control_0001 Exclusive	Viral	0.01	-0.51	2.67	0.48	5.89
Viral Exclusive	Control_0001 Exclusive	0.01	0.59	0.09	0.55	3.14
Control_0001 Exclusive	Viral Exclusive	0.01	-0.49	2.24	0.38	3.12
Viral Exclusive	Overlap	0.03	18.08	752.17	49.45	92.78
Control_0001 Exclusive	Overlap	0.00	-0.14	3.37	0.76	1.19
Overlap	Exclusives	0.07	35.10	51.23	10.29	95.84

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	106	102	SNORA31;HLA-DRB4;SRY;MBL3P
Control_0001 Exclusive	112	112	
Overlap	2	2