Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	Control_0001	7.06e-05	3.76e-01	1.60e-04	1.49e-03
Control_0001 Exclusive	Covid	1.96e-01	5.10e-02	2.63e-04	8.39e-08
Covid Exclusive	Control_0001 Exclusive	7.51e-05	6.79e-01	4.12e-04	1.40e-03
Control_0001 Exclusive	Covid Exclusive	3.06e-01	3.81e-02	2.92e-04	1.86e-07
Covid Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Control_0001 Exclusive	Overlap	1.57e-01	9.92e-02	1.12e-01	1.18e-01
Overlap	Exclusives	3.53e-21	1.13e-13	9.12e-29	9.61e-22



Evaluating how well Covid genes are linked to Control_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Control_0001	0.60	0.73	0.65	0.68	3.73
Control_0001 Exclusive	Covid	0.71	0.34	2.66	0.77	6.65
Covid Exclusive	Control_0001 Exclusive	0.60	0.64	0.30	0.54	3.43
Control_0001 Exclusive	Covid Exclusive	0.71	0.22	3.26	0.97	5.99
Covid Exclusive	Overlap	1.00	1.15	3.34	1.56	1.91
Control_0001 Exclusive	Overlap	0.94	0.52	2.23	0.95	1.74
Overlap	Exclusives	0.73	15.30	8.39	2.06	11.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Control_0001	0.01	0.38	0.38	0.90	3.61
Control_0001 Exclusive	Covid	0.01	-0.42	2.02	0.22	6.49
Covid Exclusive	Control_0001 Exclusive	0.01	-0.06	0.04	0.49	1.55
Control_0001 Exclusive	Covid Exclusive	0.01	-0.33	2.28	0.23	2.16
Covid Exclusive	Overlap	0.02	9.24	666.31	42.82	31.76
Control_0001 Exclusive	Overlap	0.00	-0.25	13.57	0.06	2.53
Overlap	Exclusives	0.04	37.54	28.92	4.54	28.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	77	74	MBL3P;HLA-DRB4;SRY
Control_0001 Exclusive	113	113	
Overlap	1	1