Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	Control_0001	4.53e-11	7.95e-02	1.13e-01	8.26e-02
Control_0001	JLC	6.68e-03	5.91e-03	1.98e-04	2.00e-05



Evaluating how well JLC genes are linked to Control_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Control_0001	0.57	-1.00	-1.21	-0.44	2.88
Control_0001	JLC	0.85	1.28	3.23	1.54	4.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Control_0001	0.01	-0.19	-0.02	0.02	1.20
Control_0001	JLC	0.00	0.27	2.89	0.47	5.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
Control_0001	114	114