Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	Control_00001	2.05e-04	8.35e-01	7.04e-01	6.82e-02
Control_00001	Viral	7.95e-02	6.89e-01	6.88e-03	6.60e-07



Evaluating how well Viral genes are linked to Control_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Control_00001	0.62	-1.10	0.06	0.12	2.72
Control_00001	Viral	0.66	-0.17	-0.06	0.33	6.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Control_00001	0.00	-0.99	-0.33	-0.20	1.30
Control_00001	Viral	0.01	-0.38	-0.50	0.20	4.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	108	104	HLA-DRB4;SNORA31;SRY;MBL3P
Control_00001	36	36