Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	Control_00001	3.57e-05	9.09e-01	7.63e-01	7.06e-02
Control_00001	Covid	3.04e-02	5.36e-01	1.01e-01	1.63e-04



Evaluating how well Covid genes are linked to Control_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	Control_00001	0.60	-1.12	-0.38	0.07	2.17
Control_00001	Covid	0.65	-0.55	-1.07	0.07	5.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	Control_00001	0.00	-0.86	-0.54	-0.25	0.63
Control_00001	Covid	0.01	-0.58	-1.26	-0.04	3.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	78	75	MBL3P;HLA-DRB4;SRY
Control_00001	36	36