Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	Control_00001	3.35e-05	2.99e-01	9.30e-01	1.08e-03
Control_00001	JLC	7.62e-01	3.57e-01	4.67e-02	3.29e-03



Evaluating how well JLC genes are linked to Control_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Control_00001	0.62	-0.73	-0.57	-0.22	2.88
Control_00001	JLC	0.77	0.44	1.43	0.79	3.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Control_00001	0.00	-0.32	-0.58	-0.16	1.41
Control_00001	JLC	0.00	-0.22	0.05	0.00	1.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
Control_00001	36	36