Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	Mild_0001	2.14e-02	1.22e-03	5.76e-04	8.47e-05
Mild_0001 Exclusive	Viral	3.60e-01	1.06e-01	8.27e-02	1.14e-08
Viral Exclusive	Mild_0001 Exclusive	2.15e-02	4.28e-03	1.23e-03	1.44e-04
Mild_0001 Exclusive	Viral Exclusive	2.75e-01	1.53e-01	9.68e-02	5.57e-09
Viral Exclusive	Overlap	9.92e-02	1.25e-01	9.92e-02	1.12e-01
Mild_0001 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	5.24e-31	3.41e-29	2.31e-36	8.93e-43



Evaluating how well Viral genes are linked to Mild_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Mild_0001	0.66	1.01	2.87	1.66	4.45
Mild_0001 Exclusive	Viral	0.67	0.42	1.24	0.56	6.86
Viral Exclusive	Mild_0001 Exclusive	0.66	1.00	2.27	1.71	4.55
Mild_0001 Exclusive	Viral Exclusive	0.67	0.30	0.89	0.52	6.41
Viral Exclusive	Overlap	0.98	2.24	2.04	1.84	1.58
Mild_0001 Exclusive	Overlap	1.00	1.77	1.68	1.83	1.57
Overlap	Exclusives	0.83	2.46	13.14	2.19	14.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Mild_0001	0.01	0.08	1.87	1.10	2.67
Mild_0001 Exclusive	Viral	0.01	-0.21	-0.50	0.08	5.92
Viral Exclusive	Mild_0001 Exclusive	0.01	0.05	1.44	1.57	2.62
Mild_0001 Exclusive	Viral Exclusive	0.01	-0.34	-0.75	0.04	1.76
Viral Exclusive	Overlap	0.00	2.61	1.03	1.41	0.25
Mild_0001 Exclusive	Overlap	0.01	42.47	38.21	66.40	63.08
Overlap	Exclusives	0.05	3.40	29.35	4.02	38.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	107	103	SRY;HLA-DRB4;SNORA31;MBL3P
Mild_0001 Exclusive	66	66	
Overlap	1	1