Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	Mild_0001	2.75e-02	6.39e-02	4.44e-04	5.79e-05
Mild_0001 Exclusive	Covid	3.53e-01	1.07e-01	6.11e-02	1.20e-06
Covid Exclusive	Mild_0001 Exclusive	1.41e-02	4.27e-02	3.66e-04	9.08e-05
Mild_0001 Exclusive	Covid Exclusive	2.48e-01	1.20e-01	1.12e-01	1.24e-06
Covid Exclusive	Overlap	9.92e-02	1.18e-01	9.92e-02	1.05e-01
Mild_0001 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	2.23e-22	3.60e-22	8.49e-26	3.94e-34



Evaluating how well Covid genes are linked to Mild_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Mild_0001	0.66	1.23	2.53	1.83	4.30
Mild_0001 Exclusive	Covid	0.68	0.26	1.48	0.57	5.63
Covid Exclusive	Mild_0001 Exclusive	0.66	1.00	2.72	2.19	4.83
Mild_0001 Exclusive	Covid Exclusive	0.68	0.08	1.34	0.48	5.61
Covid Exclusive	Overlap	0.98	1.90	1.82	1.68	1.72
Mild_0001 Exclusive	Overlap	1.00	1.79	2.03	2.04	1.86
Overlap	Exclusives	0.82	2.41	12.56	2.55	13.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Mild_0001	0.01	0.34	1.21	1.36	0.40
Mild_0001 Exclusive	Covid	0.01	-0.23	0.38	0.10	3.84
Covid Exclusive	Mild_0001 Exclusive	0.00	-0.07	1.58	1.63	0.82
Mild_0001 Exclusive	Covid Exclusive	0.01	-0.41	0.05	0.02	4.75
Covid Exclusive	Overlap	0.00	6.97	0.50	4.97	4.24
Mild_0001 Exclusive	Overlap	0.01	0.56	51.34	81.15	20.15
Overlap	Exclusives	0.04	3.02	23.03	4.72	34.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	77	74	SRY;MBL3P;HLA-DRB4
Mild_0001 Exclusive	66	66	
Overlap	1	1