Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	Mild_0001	5.63e-06	4.80e-01	5.79e-02	4.54e-03
Mild_0001	JLC	6.24e-02	4.72e-01	2.35e-01	2.91e-01



Evaluating how well JLC genes are linked to Mild_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Mild_0001	0.60	-0.56	-0.07	-0.20	3.04
Mild_0001	JLC	0.61	-0.43	-1.08	-0.54	1.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Mild_0001	0.00	-0.50	-0.27	-0.24	0.22
Mild_0001	JLC	0.00	-0.65	-1.19	-0.52	-0.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
Mild_0001	67	67