Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	Mild_00001	2.66e-04	1.62e-01	7.19e-02	1.11e-06
Mild_00001	Viral	5.14e-04	4.14e-01	5.78e-03	1.44e-04



Evaluating how well Viral genes are linked to Mild_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Mild_00001	0.69	-0.79	1.08	0.95	5.24
Mild_00001	Viral	0.64	-1.02	-1.36	0.24	4.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Mild_00001	0.00	-1.43	-0.53	0.02	3.47
Mild_00001	Viral	0.01	-0.75	-1.53	0.07	1.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	108	104	SRY;SNORA31;MBL3P;HLA-DRB4
Mild_00001	47	47