Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	Mild_00001	3.49e-04	8.62e-02	4.16e-02	1.38e-06
Mild_00001	Covid	7.35e-03	6.90e-01	9.56e-03	7.98e-05



Evaluating how well Covid genes are linked to Mild_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	Mild_00001	0.69	-0.46	1.43	1.43	4.81
Mild_00001	Covid	0.66	-0.91	-0.51	0.42	4.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	Mild_00001	0.00	-1.39	-0.29	0.53	1.89
Mild_00001	Covid	0.01	-0.88	-1.11	0.27	3.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	78	75	SRY;HLA-DRB4;MBL3P
Mild_00001	47	47