Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	Mild_00001	4.30e-04	1.78e-01	2.80e-02	4.71e-07
Mild_00001	JLC	1.34e-04	2.31e-02	3.93e-01	4.23e-01



Evaluating how well JLC genes are linked to Mild_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Mild_00001	0.68	0.70	0.42	0.45	4.26
Mild_00001	JLC	0.55	-2.39	-2.77	-0.67	0.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Mild_00001	0.00	-0.30	-1.18	-0.16	1.28
Mild_00001	JLC	0.00	-0.63	-1.46	-0.57	-0.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
Mild_00001	47	47