Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	Severe_0001	9.02e-06	7.30e-03	6.05e-06	1.07e-07
Severe_0001 Exclusive	Viral	3.21e-04	3.54e-04	3.66e-08	3.42e-15
Viral Exclusive	Severe_0001 Exclusive	4.93e-06	7.74e-03	7.54e-05	1.89e-07
Severe_0001 Exclusive	Viral Exclusive	3.66e-03	5.37e-04	4.21e-06	1.29e-14
Viral Exclusive	Overlap	1.30e-03	1.30e-03	1.30e-03	2.23e-03
Severe_0001 Exclusive	Overlap	3.16e-03	1.09e-02	1.40e-03	5.98e-03
Overlap	Exclusives	9.58e-26	3.89e-22	9.93e-42	5.60e-39



Evaluating how well Viral genes are linked to Severe_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Severe_0001	0.65	1.36	3.89	1.74	5.94
Severe_0001 Exclusive	Viral	0.75	1.33	4.80	1.77	9.13
Viral Exclusive	Severe_0001 Exclusive	0.64	1.25	3.03	1.67	6.04
Severe_0001 Exclusive	Viral Exclusive	0.74	1.04	4.34	1.38	9.60
Viral Exclusive	Overlap	0.87	2.86	3.15	2.58	3.22
Severe_0001 Exclusive	Overlap	0.86	2.13	2.83	2.42	2.45
Overlap	Exclusives	0.79	2.72	13.91	2.48	16.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Severe_0001	0.01	0.81	3.98	2.02	5.66
Severe_0001 Exclusive	Viral	0.01	0.27	2.09	1.60	13.30
Viral Exclusive	Severe_0001 Exclusive	0.01	0.27	2.36	1.47	3.41
Severe_0001 Exclusive	Viral Exclusive	0.01	0.08	1.55	0.77	9.72
Viral Exclusive	Overlap	0.01	15.75	87.54	41.05	31.71
Severe_0001 Exclusive	Overlap	0.00	3.95	6.21	7.89	3.96
Overlap	Exclusives	0.06	14.34	47.14	8.12	60.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	103	99	MBL3P;SRY;HLA-DRB4;SNORA31
Severe_0001 Exclusive	148	148	
Overlap	5	5