Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	Severe_0001	1.98e-03	1.66e-03	6.14e-08	5.86e-07
Severe_0001 Exclusive	Covid	7.05e-04	3.50e-05	7.35e-09	3.43e-13
Covid Exclusive	Severe_0001 Exclusive	5.45e-03	4.09e-03	1.12e-07	2.61e-07
Severe_0001 Exclusive	Covid Exclusive	9.78e-04	2.15e-05	1.23e-08	2.32e-12
Covid Exclusive	Overlap	7.88e-02	7.88e-02	7.88e-02	1.08e-01
Severe_0001 Exclusive	Overlap	7.88e-02	3.47e-01	7.88e-02	1.02e-01
Overlap	Exclusives	1.22e-21	1.56e-17	1.70e-51	1.24e-35



Evaluating how well Covid genes are linked to Severe_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Severe_0001	0.66	2.10	4.90	2.05	7.15
Severe_0001 Exclusive	Covid	0.78	1.55	5.12	1.76	8.75
Covid Exclusive	Severe_0001 Exclusive	0.65	2.64	3.87	1.77	6.45
Severe_0001 Exclusive	Covid Exclusive	0.78	1.90	5.33	1.95	8.33
Covid Exclusive	Overlap	0.83	1.73	1.46	1.42	1.90
Severe_0001 Exclusive	Overlap	0.79	0.94	1.07	1.07	1.63
Overlap	Exclusives	0.78	1.95	11.51	2.32	15.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Severe_0001	0.01	1.17	4.37	2.37	4.39
Severe_0001 Exclusive	Covid	0.01	0.40	2.63	1.43	9.69
Covid Exclusive	Severe_0001 Exclusive	0.01	1.47	4.20	1.80	6.23
Severe_0001 Exclusive	Covid Exclusive	0.01	0.69	2.67	1.45	11.58
Covid Exclusive	Overlap	0.00	3.00	31.09	10.93	7.70
Severe_0001 Exclusive	Overlap	0.00	2.67	1.72	5.24	1.20
Overlap	Exclusives	0.04	5.44	25.47	4.62	22.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	75	72	SRY;HLA-DRB4;MBL3P
Severe_0001 Exclusive	150	150	
Overlap	3	3