Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC Exclusive	Severe_0001	2.40e-06	6.87e-01	7.20e-02	6.19e-05
Severe_0001 Exclusive	JLC	7.30e-02	4.60e-02	2.00e-02	3.91e-04
JLC Exclusive	Severe_0001 Exclusive	5.02e-06	8.78e-01	3.40e-03	1.23e-04
Severe_0001 Exclusive	JLC Exclusive	5.73e-01	6.67e-02	1.26e-01	3.01e-03
JLC Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.22e-02
Severe_0001 Exclusive	Overlap	2.21e-02	1.43e-01	1.15e-02	2.55e-02
Overlap	Exclusives	5.00e-03	1.63e-02	1.55e-09	5.78e-08



Evaluating how well JLC genes are linked to Severe_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC Exclusive	Severe_0001	0.61	0.24	1.02	0.13	4.92
Severe_0001 Exclusive	JLC	0.82	1.16	2.90	1.41	4.09
JLC Exclusive	Severe_0001 Exclusive	0.60	0.29	0.53	0.16	3.92
Severe_0001 Exclusive	JLC Exclusive	0.80	0.94	2.14	0.86	3.03
JLC Exclusive	Overlap	1.00	3.11	2.28	2.31	2.22
Severe_0001 Exclusive	Overlap	0.95	2.20	1.80	2.31	2.08
Overlap	Exclusives	0.66	0.53	3.28	0.79	6.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC Exclusive	Severe_0001	0.01	-0.12	2.45	0.60	5.65
Severe_0001 Exclusive	JLC	0.00	0.46	0.11	1.51	2.80
JLC Exclusive	Severe_0001 Exclusive	0.01	0.64	1.07	0.50	2.16
Severe_0001 Exclusive	JLC Exclusive	0.00	-0.07	0.05	0.06	1.72
JLC Exclusive	Overlap	0.03	204.50	139.22	122.95	45.25
Severe_0001 Exclusive	Overlap	0.00	1.96	0.82	2.32	0.19
Overlap	Exclusives	0.03	3.60	20.59	4.05	14.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC Exclusive	11	10	UNC93B
Severe_0001 Exclusive	151	151	
Overlap	2	2