Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	Severe_00001	8.60e-02	3.04e-02	2.68e-04	4.01e-04
Severe_00001 Exclusive	Viral	1.13e-03	2.16e-06	8.89e-12	2.32e-18
Viral Exclusive	Severe_00001 Exclusive	1.46e-01	7.25e-02	1.90e-03	1.78e-03
Severe_00001 Exclusive	Viral Exclusive	2.30e-02	6.67e-06	5.40e-11	1.05e-17
Viral Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Severe_00001 Exclusive	Overlap	1.15e-02	1.22e-02	1.15e-02	1.65e-02
Overlap	Exclusives	8.48e-31	6.19e-28	3.32e-39	5.90e-41



Evaluating how well Viral genes are linked to Severe_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Severe_00001	0.75	1.76	2.52	2.15	4.92
Severe_00001 Exclusive	Viral	0.76	1.31	5.30	1.78	9.00
Viral Exclusive	Severe_00001 Exclusive	0.73	0.70	1.89	1.71	4.04
Severe_00001 Exclusive	Viral Exclusive	0.76	0.97	5.71	1.48	9.18
Viral Exclusive	Overlap	1.00	3.15	2.32	2.50	2.26
Severe_00001 Exclusive	Overlap	0.99	1.98	2.83	2.26	2.43
Overlap	Exclusives	0.88	2.69	13.08	2.53	16.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Severe_00001	0.01	3.92	6.09	7.23	3.69
Severe_00001 Exclusive	Viral	0.01	1.53	5.77	2.78	13.29
Viral Exclusive	Severe_00001 Exclusive	0.00	0.20	1.50	2.90	2.42
Severe_00001 Exclusive	Viral Exclusive	0.01	0.57	4.42	1.99	4.25
Viral Exclusive	Overlap	0.02	28.29	104.00	97.05	45.99
Severe_00001 Exclusive	Overlap	0.00	26.25	36.35	24.18	2.19
Overlap	Exclusives	0.09	21.50	80.19	11.00	125.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	106	102	SRY;HLA-DRB4;MBL3P;SNORA31
Severe_00001 Exclusive	22	22	
Overlap	2	2