Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	Severe_00001	1.38e-01	1.43e-02	9.72e-05	1.33e-04
Severe_00001 Exclusive	Covid	2.44e-03	2.52e-06	1.77e-10	2.72e-17
Covid Exclusive	Severe_00001 Exclusive	2.25e-01	2.31e-02	3.77e-04	4.50e-04
Severe_00001 Exclusive	Covid Exclusive	1.17e-02	1.47e-06	7.55e-10	4.81e-16
Covid Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
Severe_00001 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	3.17e-25	2.52e-20	1.33e-41	3.34e-33



Evaluating how well Covid genes are linked to Severe_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Severe_00001	0.74	0.99	2.21	2.09	3.98
Severe_00001 Exclusive	Covid	0.79	1.77	6.02	1.90	9.72
Covid Exclusive	Severe_00001 Exclusive	0.73	0.86	2.06	1.71	3.41
Severe_00001 Exclusive	Covid Exclusive	0.79	1.51	5.71	1.80	9.15
Covid Exclusive	Overlap	1.00	1.01	1.58	1.58	1.62
Severe_00001 Exclusive	Overlap	0.99	1.68	2.32	1.89	1.49
Overlap	Exclusives	0.87	2.37	9.76	2.52	12.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Severe_00001	0.00	1.35	3.68	5.38	4.91
Severe_00001 Exclusive	Covid	0.01	1.62	4.50	2.92	19.62
Covid Exclusive	Severe_00001 Exclusive	0.00	0.52	2.03	2.58	3.00
Severe_00001 Exclusive	Covid Exclusive	0.01	1.54	5.12	2.64	3.22
Covid Exclusive	Overlap	0.01	3.67	43.91	47.93	4.23
Severe_00001 Exclusive	Overlap	0.00	5.58	94.61	12.84	10.71
Overlap	Exclusives	0.06	14.23	52.29	11.00	31.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	77	74	SRY;HLA-DRB4;MBL3P
Severe_00001 Exclusive	23	23	
Overlap	1	1