Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	Control_0001	8.78e-07	7.45e-01	1.45e-02	7.64e-01
Control_0001	Viral	4.13e-01	3.84e-01	5.81e-01	4.05e-07



Evaluating how well Viral genes are linked to Control_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Control_0001	0.52	-0.01	-0.18	0.15	0.60
Control_0001	Viral	0.64	-0.05	-0.80	0.03	4.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Control_0001	0.01	0.98	-0.29	0.51	0.21
Control_0001	Viral	0.01	-0.47	-1.40	-0.35	1.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	108	104	MBL3P;HLA-DRB4;SRY;SNORA31
Control_0001	108	106	ZNF763;SYT15