Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	Control_0001	3.40e-05	7.55e-01	1.80e-01	8.32e-01
Control_0001	Covid	5.99e-01	3.07e-01	5.74e-01	7.95e-08



Evaluating how well Covid genes are linked to Control_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	Control_0001	0.52	0.20	-0.12	0.34	0.68
Control_0001	Covid	0.66	-0.06	-0.21	0.04	4.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	Control_0001	0.01	0.92	-0.35	0.44	0.11
Control_0001	Covid	0.01	-0.63	-0.89	-0.44	0.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	78	75	MBL3P;HLA-DRB4;SRY
Control_0001	108	106	SYT15;ZNF763