Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	Control_0001	4.76e-11	1.08e-01	1.04e-02	1.28e-01
Control_0001	JLC	3.01e-03	3.01e-03	8.33e-03	3.81e-01



Evaluating how well JLC genes are linked to Control_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Control_0001	0.48	-2.17	-2.07	-1.69	-0.53
Control_0001	JLC	0.53	-1.02	-2.37	-1.09	0.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Control_0001	0.00	-1.49	-1.27	-0.86	-1.07
Control_0001	JLC	0.00	-0.33	-1.51	-0.56	-0.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
Control_0001	108	106	ZNF763;SYT15