Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	Control_00001	5.58e-05	8.85e-01	3.89e-01	3.36e-01
Control_00001 Exclusive	Viral	3.31e-01	3.06e-01	1.48e-01	3.83e-06
Viral Exclusive	Control_00001 Exclusive	6.37e-05	9.00e-01	5.96e-01	4.46e-01
Control_00001 Exclusive	Viral Exclusive	3.07e-01	2.80e-01	1.43e-01	7.70e-06
Viral Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.25e-01
Control_00001 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	4.81e-26	2.03e-15	4.59e-53	1.44e-29



Evaluating how well Viral genes are linked to Control_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Control_00001	0.55	0.30	1.00	1.07	1.46
Control_00001 Exclusive	Viral	0.63	0.53	-0.44	-0.02	5.30
Viral Exclusive	Control_00001 Exclusive	0.55	0.27	0.95	1.19	1.24
Control_00001 Exclusive	Viral Exclusive	0.63	0.39	-0.46	-0.09	4.40
Viral Exclusive	Overlap	0.94	0.65	1.96	1.25	1.38
Control_00001 Exclusive	Overlap	1.00	1.97	1.26	1.61	1.73
Overlap	Exclusives	0.78	2.49	11.15	2.27	11.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Control_00001	0.00	0.25	0.16	0.50	-0.02
Control_00001 Exclusive	Viral	0.01	0.23	-1.00	-0.24	1.62
Viral Exclusive	Control_00001 Exclusive	0.00	0.19	0.25	0.48	0.13
Control_00001 Exclusive	Viral Exclusive	0.01	0.06	-1.26	-0.36	1.93
Viral Exclusive	Overlap	0.00	-0.12	6.49	0.73	0.78
Control_00001 Exclusive	Overlap	0.01	58.98	24.58	15.33	30.47
Overlap	Exclusives	0.03	5.59	17.75	1.89	26.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	107	103	HLA-DRB4;SRY;SNORA31;MBL3P
Control_00001 Exclusive	59	57	ZNF763;SYT15
Overlap	1	1