Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid Exclusive	Control_00001	4.71e-03	3.20e-01	2.53e-01	2.83e-01
Control_00001 Exclusive	Covid	7.87e-01	6.84e-01	5.17e-01	1.54e-05
Covid Exclusive	Control_00001 Exclusive	4.96e-03	4.73e-01	4.07e-01	3.36e-01
Control_00001 Exclusive	Covid Exclusive	8.62e-01	4.14e-01	7.42e-01	3.51e-05
Covid Exclusive	Overlap	1.05e-01	9.92e-02	1.05e-01	1.25e-01
Control_00001 Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	1.05e-01
Overlap	Exclusives	9.56e-21	6.62e-13	2.94e-38	6.49e-23



Evaluating how well Covid genes are linked to Control_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Control_00001	0.57	0.78	1.36	1.34	2.01
Control_00001 Exclusive	Covid	0.66	0.67	0.51	0.12	4.92
Covid Exclusive	Control_00001 Exclusive	0.56	0.65	1.23	1.20	1.51
Control_00001 Exclusive	Covid Exclusive	0.65	0.62	0.06	0.25	4.09
Covid Exclusive	Overlap	0.94	0.66	1.35	1.18	1.71
Control_00001 Exclusive	Overlap	1.00	1.89	1.34	1.81	1.87
Overlap	Exclusives	0.77	2.22	8.88	2.51	10.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid Exclusive	Control_00001	0.00	0.62	0.40	0.49	0.01
Control_00001 Exclusive	Covid	0.01	0.42	-0.09	-0.10	3.32
Covid Exclusive	Control_00001 Exclusive	0.00	0.23	0.15	0.50	0.22
Control_00001 Exclusive	Covid Exclusive	0.01	0.22	-0.64	-0.20	2.05
Covid Exclusive	Overlap	0.00	-0.10	5.19	0.01	0.24
Control_00001 Exclusive	Overlap	0.01	47.23	28.69	32.77	7.91
Overlap	Exclusives	0.02	5.05	15.15	2.25	20.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid Exclusive	77	74	HLA-DRB4;SRY;MBL3P
Control_00001 Exclusive	59	57	SYT15;ZNF763
Overlap	1	1