Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	Control_00001	2.77e-06	3.73e-01	6.12e-02	5.50e-02
Control_00001	JLC	6.65e-02	4.76e-01	2.12e-01	1.59e-01



Evaluating how well JLC genes are linked to Control_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Control_00001	0.54	0.00	0.33	0.13	1.12
Control_00001	JLC	0.59	-0.84	-0.71	-0.45	0.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Control_00001	0.00	-0.38	-0.75	-0.50	-0.23
Control_00001	JLC	0.00	-0.49	-0.98	-0.54	-0.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
Control_00001	60	58	ZNF763;SYT15