Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	Mild_0001	2.12e-15	3.88e-01	2.24e-03	6.14e-02
Mild_0001	Viral	1.32e-06	2.36e-05	1.33e-05	1.91e-01



Evaluating how well Viral genes are linked to Mild_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Mild_0001	0.51	-1.20	-1.22	-0.56	0.47
Mild_0001	Viral	0.53	-2.26	-6.57	-2.05	1.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Mild_0001	0.01	-1.17	-0.94	-0.79	-0.69
Mild_0001	Viral	0.01	-1.46	-4.67	-1.13	-0.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	108	104	MBL3P;SNORA31;HLA-DRB4;SRY
Mild_0001	157	157