Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	Mild_0001	1.48e-11	6.98e-01	1.57e-01	7.29e-02
Mild_0001	JLC	4.37e-02	2.15e-02	7.08e-02	6.58e-01



Evaluating how well JLC genes are linked to Mild_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Mild_0001	0.53	-1.05	-0.14	-0.44	1.37
Mild_0001	JLC	0.52	-1.12	-3.41	-1.33	0.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Mild_0001	0.01	-1.09	-0.99	-0.73	-0.17
Mild_0001	JLC	0.00	-0.69	-1.57	-0.75	-0.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
Mild_0001	157	157