Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	Mild_00001	2.15e-01	3.80e-01	1.90e-01	2.41e-01
Mild_00001	Viral	2.48e-04	1.03e-02	3.21e-03	6.18e-04



Evaluating how well Viral genes are linked to Mild_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Mild_00001	0.54	0.47	0.68	0.80	0.74
Mild_00001	Viral	0.61	-0.59	-3.50	-0.51	4.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Mild_00001	0.00	0.08	-0.17	-0.08	-0.04
Mild_00001	Viral	0.01	-0.41	-1.88	-0.37	1.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	108	104	SNORA31;MBL3P;SRY;HLA-DRB4
Mild_00001	22	22