Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	Mild_00001	7.23e-01	3.00e-01	8.85e-02	1.81e-01
Mild_00001	Covid	3.42e-03	6.07e-02	1.62e-02	8.56e-04



Evaluating how well Covid genes are linked to Mild_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	Mild_00001	0.55	0.96	0.73	0.91	1.03
Mild_00001	Covid	0.62	-0.51	-2.67	-0.60	3.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	Mild_00001	0.00	0.49	0.12	0.36	-0.08
Mild_00001	Covid	0.01	-0.30	-1.37	-0.40	0.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	78	75	HLA-DRB4;SRY;MBL3P
Mild_00001	22	22