Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	Mild_00001	1.16e-02	7.76e-01	9.05e-01	9.42e-01
Mild_00001	JLC	3.61e-01	4.23e-02	1.09e-01	1.55e-03



Evaluating how well JLC genes are linked to Mild_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Mild_00001	0.48	-0.69	-0.86	-0.46	-0.26
Mild_00001	JLC	0.69	0.23	0.63	0.48	2.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Mild_00001	0.00	-0.30	-0.58	-0.43	-0.28
Mild_00001	JLC	0.00	-0.27	-0.28	-0.14	0.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
Mild_00001	22	22