Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral Exclusive	Severe_0001	1.39e-14	8.34e-01	1.23e-03	9.93e-02
Severe_0001 Exclusive	Viral	1.09e-02	2.65e-01	9.73e-02	3.10e-05
Viral Exclusive	Severe_0001 Exclusive	1.62e-14	8.47e-01	8.11e-04	6.44e-02
Severe_0001 Exclusive	Viral Exclusive	9.86e-03	1.95e-01	1.08e-01	1.00e-04
Viral Exclusive	Overlap	4.52e-01	9.60e-01	8.72e-01	7.54e-01
Severe_0001 Exclusive	Overlap	4.40e-01	1.54e-01	2.50e-01	3.87e-02
Overlap	Exclusives	1.13e-17	1.14e-11	6.99e-05	2.17e-03



Evaluating how well Viral genes are linked to Severe_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Severe_0001	0.52	0.24	-0.49	0.09	1.07
Severe_0001 Exclusive	Viral	0.63	-0.83	-1.04	-0.48	4.57
Viral Exclusive	Severe_0001 Exclusive	0.52	0.37	-0.61	0.13	1.36
Severe_0001 Exclusive	Viral Exclusive	0.62	-0.76	-1.02	-0.63	4.21
Viral Exclusive	Overlap	0.60	-0.06	-0.15	-0.03	0.42
Severe_0001 Exclusive	Overlap	0.83	1.19	1.33	1.35	1.77
Overlap	Exclusives	0.48	-1.88	-8.08	-1.69	-0.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral Exclusive	Severe_0001	0.01	0.17	-0.85	-0.10	-0.02
Severe_0001 Exclusive	Viral	0.01	-1.01	-0.96	-0.71	2.53
Viral Exclusive	Severe_0001 Exclusive	0.01	0.44	-0.88	-0.03	0.07
Severe_0001 Exclusive	Viral Exclusive	0.01	-0.97	-1.37	-0.83	2.03
Viral Exclusive	Overlap	0.00	-0.66	-0.60	-0.33	-0.32
Severe_0001 Exclusive	Overlap	0.00	-0.15	-0.41	-0.13	0.31
Overlap	Exclusives	0.02	-1.24	-4.26	-0.95	-0.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral Exclusive	106	102	HLA-DRB4;MBL3P;SRY;SNORA31
Severe_0001 Exclusive	214	214	
Overlap	2	2