Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	Severe_0001	2.49e-18	8.65e-02	1.61e-02	1.48e-02
Severe_0001	JLC	5.23e-03	5.33e-03	1.48e-03	1.97e-01



Evaluating how well JLC genes are linked to Severe_0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Severe_0001	0.50	-0.88	-2.11	-1.11	-0.16
Severe_0001	JLC	0.51	-1.15	-2.15	-1.68	0.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Severe_0001	0.01	-0.87	-2.16	-1.11	-1.26
Severe_0001	JLC	0.00	-0.54	-0.38	-0.54	-0.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
Severe_0001	216	216