Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Viral	Severe_00001	1.84e-05	2.27e-01	3.23e-02	9.69e-01
Severe_00001	Viral	4.58e-08	6.43e-04	2.34e-05	6.06e-03



Evaluating how well Viral genes are linked to Severe_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Severe_00001	0.49	-1.94	-1.80	-1.14	-0.16
Severe_00001	Viral	0.55	-1.51	-7.01	-1.48	1.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Viral	Severe_00001	0.00	-1.46	-0.92	-0.96	-0.41
Severe_00001	Viral	0.01	-0.99	-4.17	-0.98	-0.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Viral	108	104	HLA-DRB4;SRY;SNORA31;MBL3P
Severe_00001	28	28