Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Covid	Severe_00001	2.30e-04	5.42e-01	3.00e-01	5.99e-01
Severe_00001	Covid	2.29e-04	6.09e-03	1.97e-02	3.17e-03



Evaluating how well Covid genes are linked to Severe_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	Severe_00001	0.49	-1.77	-1.48	-1.06	-0.17
Severe_00001	Covid	0.57	-1.05	-5.28	-1.45	2.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Covid	Severe_00001	0.00	-1.30	-0.75	-1.00	-0.59
Severe_00001	Covid	0.00	-0.81	-3.37	-0.81	-0.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Covid	78	75	MBL3P;HLA-DRB4;SRY
Severe_00001	28	28