Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	Severe_00001	1.90e-03	2.96e-01	1.45e-01	3.98e-01
Severe_00001	JLC	8.17e-03	6.41e-03	1.21e-02	4.27e-01



Evaluating how well JLC genes are linked to Severe_00001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Severe_00001	0.57	-0.15	-0.12	0.00	1.37
Severe_00001	JLC	0.53	-0.76	-3.23	-1.00	0.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	Severe_00001	0.00	-0.36	-0.63	-0.36	-0.15
Severe_00001	JLC	0.00	-0.35	-1.84	-0.63	-0.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
Severe_00001	28	28