Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	Collection_GS	4.58e-01	6.35e-01	7.94e-02	1.39e-09
Collection_GS Exclusive	gene_list	2.04e-01	7.57e-01	7.64e-01	4.33e-01
gene_list Exclusive	Collection_GS Exclusive	1.45e-01	5.04e-01	7.10e-02	5.33e-09
Collection_GS Exclusive	gene_list Exclusive	1.28e-01	4.65e-01	6.29e-01	2.40e-01
gene_list Exclusive	Overlap	1.18e-01	1.41e-01	9.92e-02	1.12e-01
Collection_GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	9.19e-26	4.80e-31	8.17e-28	2.96e-34



Evaluating how well gene_list genes are linked to Collection_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	Collection_GS	0.67	-0.75	-0.59	-0.71	5.11
Collection_GS Exclusive	gene_list	0.48	-0.18	-0.27	-0.55	-0.41
gene_list Exclusive	Collection_GS Exclusive	0.67	-0.90	-0.85	-0.81	4.78
Collection_GS Exclusive	gene_list Exclusive	0.45	-0.93	-0.98	-1.13	-0.87
gene_list Exclusive	Overlap	0.98	1.61	2.03	2.06	1.57
Collection_GS Exclusive	Overlap	1.00	3.61	1.98	2.07	1.89
Overlap	Exclusives	0.84	2.86	10.64	3.23	11.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	Collection_GS	0.01	-0.64	-1.08	-0.81	1.26
Collection_GS Exclusive	gene_list	0.01	45.27	6.88	17.11	28.11
gene_list Exclusive	Collection_GS Exclusive	0.01	-0.59	-1.17	-0.90	1.05
Collection_GS Exclusive	gene_list Exclusive	0.00	-0.68	-0.46	-0.91	-0.18
gene_list Exclusive	Overlap	0.00	2.16	0.64	3.00	3.41
Collection_GS Exclusive	Overlap	0.25	6584.35	1471.49	923.75	2753.99
Overlap	Exclusives	0.12	28.96	159.68	34.67	193.60

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	20	20	
Collection_GS Exclusive	86	86	
Overlap	1	1