Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
gene_list Exclusive	GS	9.92e-01	9.77e-01	3.98e-01	3.33e-06
GS Exclusive	gene_list	5.18e-01	4.96e-01	3.63e-04	9.93e-01
gene_list Exclusive	GS Exclusive	9.72e-01	9.98e-01	4.35e-01	1.33e-05
GS Exclusive	gene_list Exclusive	3.70e-01	6.29e-01	8.77e-04	9.57e-01
gene_list Exclusive	Overlap	7.27e-01	3.83e-01	5.27e-01	2.75e-01
GS Exclusive	Overlap	1.15e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	8.45e-09	1.39e-10	1.10e-14	1.36e-11



Evaluating how well gene_list genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.67	0.23	0.14	-0.25	4.40
GS Exclusive	gene_list	0.50	2.29	1.43	1.12	-0.07
gene_list Exclusive	GS Exclusive	0.67	0.24	0.08	-0.20	4.75
GS Exclusive	gene_list Exclusive	0.50	2.06	0.98	0.86	0.01
gene_list Exclusive	Overlap	0.65	0.22	0.65	0.64	0.85
GS Exclusive	Overlap	1.00	3.96	2.38	3.07	2.59
Overlap	Exclusives	0.61	2.28	4.47	2.13	6.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
gene_list Exclusive	GS	0.01	-0.06	-0.24	-0.60	3.64
GS Exclusive	gene_list	0.01	3.80	4.18	4.69	3.47
gene_list Exclusive	GS Exclusive	0.01	-0.01	-0.12	-0.57	3.08
GS Exclusive	gene_list Exclusive	0.01	0.36	-0.02	-0.17	-0.44
gene_list Exclusive	Overlap	0.00	-0.40	-0.10	-0.09	-0.17
GS Exclusive	Overlap	0.42	3736.46	3030.93	2756.34	794.67
Overlap	Exclusives	0.09	35.91	84.82	28.20	77.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
gene_list Exclusive	194	187	TVP23B;ZSCAN32;UTS2B;FAM127B;KMT2E;PRAG1;KRTAP7-1
GS Exclusive	85	85	
Overlap	2	2