Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
JLC	AF0001	5.31e-05	8.12e-01	4.33e-01	9.02e-03
AF0001	JLC	9.38e-01	8.91e-01	9.83e-01	1.59e-01



Evaluating how well JLC genes are linked to AF0001 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	AF0001	0.58	0.34	0.40	-0.14	2.52
AF0001	JLC	0.65	0.20	0.00	0.01	1.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
JLC	AF0001	0.00	-0.17	-0.12	-0.25	0.38
AF0001	JLC	0.00	-0.21	-0.08	-0.25	0.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
JLC	13	12	UNC93B
AF0001	78	78