Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML Exclusive	Familial GS	1.13e-01	1.40e-01	3.13e-01	6.16e-08
Familial GS Exclusive	EAML	1.65e-02	7.02e-01	1.19e-02	7.04e-02
EAML Exclusive	Familial GS Exclusive	6.59e-02	1.28e-01	5.30e-01	3.79e-07
Familial GS Exclusive	EAML Exclusive	1.18e-02	6.46e-01	6.82e-03	8.88e-02
EAML Exclusive	Overlap	5.30e-01	3.35e-01	1.75e-01	5.30e-01
Familial GS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	7.03e-04	1.62e-03	1.62e-12	8.50e-05



Evaluating how well EAML genes are linked to Familial GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	Familial GS	0.79	1.04	1.83	0.22	5.62
Familial GS Exclusive	EAML	0.44	0.24	-0.37	-0.87	-1.92
EAML Exclusive	Familial GS Exclusive	0.79	1.13	1.97	0.20	5.84
Familial GS Exclusive	EAML Exclusive	0.44	0.15	-0.57	-0.88	-1.79
EAML Exclusive	Overlap	0.73	-0.43	-0.78	-1.11	0.66
Familial GS Exclusive	Overlap	1.00	0.85	1.63	1.92	1.74
Overlap	Exclusives	0.57	0.99	0.90	0.64	2.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	Familial GS	0.00	0.77	0.91	-0.35	4.72
Familial GS Exclusive	EAML	0.00	0.92	2.12	0.23	0.09
EAML Exclusive	Familial GS Exclusive	0.00	1.02	0.93	-0.24	3.37
Familial GS Exclusive	EAML Exclusive	0.00	0.97	0.74	-0.12	-0.61
EAML Exclusive	Overlap	0.00	-0.54	-1.28	-0.53	-0.18
Familial GS Exclusive	Overlap	0.01	0.36	58.47	56.44	16.88
Overlap	Exclusives	0.02	14.03	19.48	5.85	18.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML Exclusive	79	77	UGT2A1;C11orf97
Familial GS Exclusive	30	30	
Overlap	1	1