Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet Exclusive	Somatic GS	1.13e-01	1.60e-01	3.22e-17	1.68e-16
Somatic GS Exclusive	wavelet	2.21e-06	2.58e-03	2.95e-34	9.80e-27
wavelet Exclusive	Somatic GS Exclusive	3.45e-01	6.97e-01	1.91e-11	9.39e-12
Somatic GS Exclusive	wavelet Exclusive	2.59e-04	2.35e-03	8.28e-29	2.29e-23
wavelet Exclusive	Overlap	1.34e-02	2.68e-03	5.81e-09	3.50e-08
Somatic GS Exclusive	Overlap	5.33e-09	5.34e-07	5.33e-09	8.99e-09
Overlap	Exclusives	9.72e-11	5.11e-05	5.21e-35	1.56e-31



Evaluating how well wavelet genes are linked to Somatic GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	Somatic GS	0.91	-0.71	1.82	2.46	9.26
Somatic GS Exclusive	wavelet	0.77	-2.31	3.45	3.54	11.88
wavelet Exclusive	Somatic GS Exclusive	0.88	-0.78	1.12	2.21	8.07
Somatic GS Exclusive	wavelet Exclusive	0.76	-2.21	3.31	2.86	10.85
wavelet Exclusive	Overlap	0.98	0.84	2.03	2.55	4.84
Somatic GS Exclusive	Overlap	0.99	1.78	3.59	3.26	5.16
Overlap	Exclusives	0.80	1.33	6.11	3.25	14.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet Exclusive	Somatic GS	0.08	1.18	4.63	23.94	136.40
Somatic GS Exclusive	wavelet	0.03	-0.63	5.18	11.23	17.50
wavelet Exclusive	Somatic GS Exclusive	0.08	0.95	7.03	26.47	239.05
Somatic GS Exclusive	wavelet Exclusive	0.02	-1.42	2.06	6.24	10.31
wavelet Exclusive	Overlap	0.02	1.84	2.35	18.84	74.27
Somatic GS Exclusive	Overlap	0.05	4.74	54.14	75.99	31.78
Overlap	Exclusives	0.05	5.52	20.54	21.32	73.76

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet Exclusive	146	145	CHD2
Somatic GS Exclusive	31	31	
Overlap	9	9