Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	Somatic GS	2.64e-02	6.45e-01	4.30e-03	6.88e-05
Somatic GS	EPI	5.12e-04	2.07e-01	7.11e-04	1.22e-02



Evaluating how well EPI genes are linked to Somatic GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Somatic GS	0.70	-2.56	-1.05	-1.93	4.30
Somatic GS	EPI	0.42	-0.42	-1.75	-2.09	-2.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Somatic GS	0.00	-1.69	-1.16	-1.44	3.33
Somatic GS	EPI	0.00	-0.52	-0.57	-1.54	-1.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	114	113	DKK 3.00
Somatic GS	40	40