Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	Familial GS	6.91e-02	1.21e-01	3.52e-03	7.89e-03
Familial GS	EPI	7.51e-05	1.36e-01	1.22e-03	7.82e-03



Evaluating how well EPI genes are linked to Familial GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Familial GS	0.67	-1.70	-2.67	-1.82	3.44
Familial GS	EPI	0.41	-0.58	-2.34	-2.38	-3.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Familial GS	0.00	-1.24	-1.71	-1.10	0.94
Familial GS	EPI	0.00	-0.08	-1.67	-1.08	-1.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	114	113	DKK 3.00
Familial GS	31	31