Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	Germline	4.94e-02	1.43e-01	1.11e-03	1.84e-03
Germline	EPI	1.12e-03	5.41e-01	1.35e-01	8.71e-02



Evaluating how well EPI genes are linked to Germline genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Germline	0.61	-1.26	-2.24	-1.26	3.10
Germline	EPI	0.45	0.04	-1.07	-0.94	-1.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Germline	0.00	-1.20	-1.81	-1.24	0.77
Germline	EPI	0.00	-0.25	-1.11	-1.17	-1.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	114	113	DKK 3.00
Germline	58	58