Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Genegroup1	Genegroup2	5.12e-01	6.27e-01	1.22e-01	7.74e-01
Genegroup2	Genegroup1	8.12e-01	8.96e-01	9.12e-01	5.06e-01



Evaluating how well Genegroup1 genes are linked to Genegroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Genegroup1	Genegroup2	0.54	-0.31	-0.37	-0.88	0.16
Genegroup2	Genegroup1	0.38	-0.69	-0.55	-0.93	-0.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Genegroup1	Genegroup2	0.00	-0.36	-0.37	-0.35	-0.35
Genegroup2	Genegroup1	0.00	-0.41	-0.21	-0.32	-0.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Genegroup1	5	5	
Genegroup2	4	3	Parkin